Simon Chivers Selected Research

pyrrolo(2,1-c)(1,4)benzodiazepine

1/2022	Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers.
10/2018	Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.

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Simon Chivers Research Topics

Disease

4	Neoplasms (Cancer) 01/2022 - 01/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 10/2018
1	Lymphoma (Lymphomas) 01/2018
1	Leukemia 01/2018
1	Bone Resorption 06/2017
1	Inborn Genetic Diseases (Disease, Hereditary) 06/2017
1	Hypophosphatasia 06/2017

Drug/Important Bio-Agent (IBA)

4	Immunoconjugates (Immunoconjugate)IBA 01/2022 - 01/2018
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2018
2	pyrrolo(2,1-c)(1,4)benzodiazepineIBA 01/2022 - 10/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	monomethyl auristatin EIBA 01/2022
1	olaparibIBA 01/2022
1	auristatinIBA 01/2022
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022
1	Lipoprotein(a)IBA 01/2022
1	Small Interfering RNA (siRNA)IBA 01/2022
1	Programmed Cell Death 1 ReceptorIBA 01/2020
1	glutamate carboxypeptidaseIBA 10/2018
1	Histones (Histone)IBA 10/2018
1	MEDI3726IBA 10/2018
1	AntigensIBA 10/2018
1	loncastuximab tesirineIBA 01/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2018
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2018
1	CD19 AntigensIBA 01/2018
1	Tubulin ModulatorsIBA 01/2018
1	Parathyroid Hormone (Parathormone)IBA 06/2017
1	EnzymesIBA 06/2017
1	OsteocalcinIBA 06/2017
1	Monoclonal AntibodiesIBA 06/2017
1	Procollagen Type IIBA 06/2017
1	Alkaline PhosphataseIBA 06/2017
1	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 06/2017
1	Collagen Type I (Type I Collagen)IBA 06/2017
1	collagen type I trimeric cross-linked peptideIBA 06/2017
1	setrusumabIBA 06/2017

Therapy/Procedure

1	Immunotherapy 01/2020
1	Castration 10/2018